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Tpm1tm1Jse
Targeted Allele Detail
Nomenclature
Symbol: Tpm1tm1Jse
Name: tropomyosin 1, alpha; targeted mutation 1, Jonathan G Seidman
MGI ID: MGI:2385810
Gene: Tpm1  Location: Chr9:67022590-67049406 bp, - strand  Genetic Position: Chr9, 36.27 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:44952
Parent Cell Line:  C1 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe neo gene was inserted in the opposite orientation via homologous recombination at a splice junction between intron 8 and exon 9a, which also deletes 32 bp of endogenous DNA. Northern blot of E8.5 embryos using probes to exon 9a and exon 9d did not detect gene transcripts in homozygous mutants. (J:44952)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 13 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tpm1 Mutation:  8 strains or lines available
References
Original:  J:44952 Blanchard EM, et al., Targeted ablation of the murine alpha-tropomyosin gene. Circ Res. 1997 Dec;81(6):1005-10
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory