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Transgene Detail
Symbol: Tg(Cyp19)C2-3Rrte
Name: transgene insertion C2-3, Rajeshwar Rao Tekmal
MGI ID: MGI:2385806
Synonyms: int-5-aromatase, MMTV-int-5-aromatase transgene
Transgene: Tg(Cyp19)C2-3Rrte  Location: unknown  
Strain of Origin:  (C57BL/6 x BALB/c)F1
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(Cyp19)C2-3Rrte expresses 1 gene
Mutation detailsThis transgene was produced using a vector that contained the 2.4kb full-length mouse Cyp 19 cDNA in addition to a coding region that included -45 to -1 of 5' and a complete (860bp) 3' untranslated region under the control of a mouse mammary tumor virus promoter (MMTV). Multiple lines were generated, ranging in copy number from 1 to 30, estimated by Southern blot. This allele is representative of the high copy number variants and carries an estimated 20 copies of the gene in mammary gland tissue. (J:34063)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:34063 Tekmal RR, et al., Overexpression of int-5/aromatase in mammary glands of transgenic mice results in the induction of hyperplasia and nuclear abnormalities. Cancer Res. 1996 Jul 15;56(14):3180-5
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory