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Targeted Allele Detail
Symbol: Ren1tm1Mgfs
Name: renin 1 structural; targeted mutation 1, Matthew G F Sharp
MGI ID: MGI:2385802
Synonyms: Ren-1d-
Gene: Ren1  Location: Chr1:133350674-133360320 bp, + strand  Genetic Position: Chr1, 57.91 cM
Altered renal morphology in Ren1tm1Mgfs/Ren1tm1Mgfs mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:41714
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA PGK-neomycin resistance cassette replaced 92 bp of exon 3, the third intron, and 35 bp of exon 4. RT-PCR analysis of kidney did not detect mRNA. (J:41714)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ren1 Mutation:  7 strains or lines available
Original:  J:41714 Clark AF, et al., Renin-1 is essential for normal renal juxtaglomerular cell granulation and macula densa morphology. J Biol Chem. 1997 Jul 18;272(29):18185-90
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory