About   Help   FAQ
Targeted Allele Detail
Symbol: Slc26a4tm1Egr
Name: solute carrier family 26, member 4; targeted mutation 1, Eric D Green
MGI ID: MGI:2385787
Synonyms: Pds-, Slc26a4delta
Gene: Slc26a4  Location: Chr12:31519827-31559969 bp, - strand  Genetic Position: Chr12, 13.53 cM, cytoband B1
Germline Transmission:  Earliest citation of germline transmission: J:67072
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 8 was replaced with a neomycin selection cassette via homologous recombination. While, normal transcript was undetected by RT-PCR and Northern blot analyses of total kidney RNA isolated from homozygous mutant mice, RT-PCR revealed the presence of an aberrant transcript containing a portion of the neo cassette. (J:67072)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 6 assay results
In Structures Affected by this Mutation: 16 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Slc26a4 Mutation:  22 strains or lines available
Original:  J:67072 Everett LA, et al., Targeted disruption of mouse Pds provides insight about the inner-ear defects encountered in Pendred syndrome. Hum Mol Genet. 2001 Jan 15;10(2):153-61
All:  35 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.15
The Jackson Laboratory