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Lhx1tm3Bhr
Targeted Allele Detail
Nomenclature
Symbol: Lhx1tm3Bhr
Name: LIM homeobox protein 1; targeted mutation 3, Richard R Behringer
MGI ID: MGI:2385727
Gene: Lhx1  Location: Chr11:84518284-84525535 bp, - strand  Genetic Position: Chr11, 51.31 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:63192
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Mutation
description
Allele Type:    Targeted (Inserted expressed sequence, Null/knockout)
Mutation:    Disruption caused by insertion of vector
 
Mutation detailsA floxed neo cassette was inserted into intron 1 via homologous recombination. The 5' and 3' arms of homology were modified to contain two missense mutations affecting conserved cysteine residues in both exons 1 and 2, which encode the LIM domains essential for zinc-finger structure. (J:63192)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lhx1 Mutation:  14 strains or lines available
References
Original:  J:63192 Cheah SS, et al., Requirement of LIM domains for LIM1 function in mouse head development. Genesis. 2000 May;27(1):12-21
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory