Lhx1^tm3Bhr
Targeted Allele Detail

Summary

• Symbol: Lhx1^tm3Bhr
• Name: LIM homeobox protein 1; targeted mutation 3, Richard R Behringer
• MGI ID: MGI:2385727
• Gene: Lhx1 Location: Chr11:84409110-84416361 bp, - strand Genetic Position: Chr11, 51.31 cM
• Alliance: Lhx1^tm3Bhr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:63192
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Null/knockout)
• Mutation: Disruption caused by insertion of vector
• Mutation details: A floxed neo cassette was inserted into intron 1 via homologous recombination. The 5' and 3' arms of homology were modified to contain two missense mutations affecting conserved cysteine residues in both exons 1 and 2, which encode the LIM domains essential for zinc-finger structure. (J:63192)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lhx1 Mutation: 22 strains or lines available

References

• Original: J:63192 Cheah SS, et al., Requirement of LIM domains for LIM1 function in mouse head development. Genesis. 2000 May;27(1):12-21
• All: 1 reference(s)