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Targeted Allele Detail
Symbol: Lhx1tm1Tmj
Name: LIM homeobox protein 1; targeted mutation 1, Thomas M Jessell
MGI ID: MGI:2385717
Synonyms: Lhx1LacZ, Lim1lacZ, Lim1-lacZ, Lim1tlz, Limtlz
Gene: Lhx1  Location: Chr11:84518284-84525535 bp, - strand  Genetic Position: Chr11, 51.31 cM
Germline Transmission:  Earliest citation of germline transmission: J:42219
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe entire coding region of the endogenous gene was replaced with an IRES-tau-lacZ-floxed neo cassette via homologous recombination. The neo cassette was excised from targeted ES cells by the transient transfection of cre expressing plasmids. The expression pattern of beta-galactosidase was similar to that of the endogenous gene. (J:42219, J:63423)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 140 assay results
In Structures Affected by this Mutation: 17 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lhx1 Mutation:  14 strains or lines available
J:42219 and J:63423 give W95 as the ES cell line. The strain of origin is given in J:63423 supplemental data as 129/Sv.
Original:  J:42219 Shawlot W, et al., Lim1 is required in both primitive streak-derived tissues and visceral endoderm for head formation in the mouse. Development. 1999 Nov;126(22):4925-32
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory