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Tg(Rbp3-SV40)IT-2Jjw
Transgene Detail
Nomenclature
Symbol: Tg(Rbp3-SV40)IT-2Jjw
Name: transgene insertion IT-2, Jolene J Windle
MGI ID: MGI:2385652
Synonyms: IRBP-Tag
Transgene: Tg(Rbp3-SV40)IT-2Jjw  Location: unknown  
Transgene
origin
Strain of Origin:  (BALB/cAnNHsd x C57BL/6NHsd)F2
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation details2.7 kb of the SV40 T antigen gene fused to 1.9 kb of mouse RBP3 promoter sequences was used as the transgene. Promoter sequences from -1783 to +101 were used to drive expression of the transgene in photoreceptor cells. Northern blot analysis confirmed transgene expression in the retina and pineal of transgenic animals. (J:60231)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Notes
Transgenic animals develop retinal and pineal tumors by 10-12 weeks of age with 100% penetrance. Transgenic animals carrying the greatest transgene copy number (15-50) also displayed a 25%-30% decrease in body weight compared to non-transgenic animals.
References
Original:  J:60231 Howes KA, et al., Photoreceptor cell tumors in transgenic mice. Invest Ophthalmol Vis Sci. 1994 Feb;35(2):342-51
All:  3 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory