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Transgene Detail
Symbol: Tg(APPSWE)2576Kha
Name: transgene insertion 2576, Karen Hsiao Ashe
MGI ID: MGI:2385631
Synonyms: APP695swe, APPK670N,M671L, APPSw, APPswe Tg2576, hAPP, K670N/M671L, Tg2576, Tg(APPSWE)2576HKahs, Tg(APPSWE)2576Kahs, Tg(HuAPP695.K670-M671L)2576, TgN(APPSWE)2576
Transgene: Tg(APPSWE)2576Kha  Location: unknown  
Increase of amyloid beta deposits and amyloid beta 40 in the hippocampus and cortex of Vps35Gt(RRK261)Byg/Vps35+ Tg(APPSWE)2576Kha/0 mice

Show the 1 phenotype image(s) involving this allele.

Strain of Origin:  (C57BL/6 x SJL)F1
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(APPSWE)2576Kha expresses 1 gene
Mutation detailsOverexpression of the human APP gene encoding the APP695.SWE mutation (K670N and M671L). The construct contained the APP gene fused to the hamster prion protein promoter. APP expression was measured in brains of transgenic mice by quantitation of immunoblots. (J:29880, J:80638)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 5 strains available      Cell Lines: 0 lines available
Original:  J:80638 Hsiao K, et al., Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science. 1996 Oct 4;274(5284):99-102
All:  701 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.21
The Jackson Laboratory