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Targeted Allele Detail
Symbol: Mapttm1Hnd
Name: microtubule-associated protein tau; targeted mutation 1, Hana N Dawson
MGI ID: MGI:2385630
Synonyms: MaptKO(Duke), TAU-
Gene: Mapt  Location: Chr11:104231390-104332090 bp, + strand  Genetic Position: Chr11, 67.79 cM, cytoband E1
Germline Transmission:  Earliest citation of germline transmission: J:78649
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 1, encoding the translational start site, was replaced by a neomycin selection cassette via homologous recombination. RT-PCR analysis of total brain RNA obtained from homozygous mutant mice showed a lack of transcript produced by the targeted locus. The absence of encoded protein was verified by Western blot analysis of brain homogenates as well as by immunocytochemical analysis of coronal sections. (J:78649)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 7 strains available      Cell Lines: 0 lines available
Carrying any Mapt Mutation:  397 strains or lines available
Original:  J:78649 Dawson HN, et al., Inhibition of neuronal maturation in primary hippocampal neurons from tau deficient mice. J Cell Sci. 2001 Mar;114(Pt 6):1179-87
All:  72 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
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