Pik3cd^tm1Bvan
Targeted Allele Detail

Summary

• Symbol: Pik3cd^tm1Bvan
• Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; targeted mutation 1, Bart Vanhaesebroeck
• MGI ID: MGI:2385595
• Synonyms: p110delta^lz
• Gene: Pik3cd Location: Chr4:149733625-149787023 bp, - strand Genetic Position: Chr4, 80.15 cM
• Alliance: Pik3cd^tm1Bvan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:78412
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Nucleotide substitutions
• Mutation details: A point mutation was introduced via homologous recombination altering the DFG motif in the C-terminal kinase domain to AFG, and a myc tag and floxed -neo-lacZ cassette were inserted after the stop codon. Southern blot confirmed the presence of the mutation in chimeric animals. (J:78412)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Pik3cd Mutation: 43 strains or lines available

References

• Original: J:78412 Okkenhaug K, et al., Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice. Science. 2002 Aug 9;297(5583):1031-4
• All: 1 reference(s)