Tg(Tuba1-MAPT)14Vle
Transgene Detail
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Symbol: |
Tg(Tuba1-MAPT)14Vle |
Name: |
transgene insertion 14, Virginia M Y Lee |
MGI ID: |
MGI:2385585 |
Synonyms: |
Talpha1-3RT |
Transgene: |
Tg(Tuba1-MAPT)14Vle Location: unknown
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Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(Tuba1-MAPT)14Vle expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
Human |
MAPT (4137) |
Mapt |
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Mutation details: A murine Tuba1 promoter was adjoined to a minigene comprised of the complete coding region of the MAPT gene that included modified intronic sequence flanking exons 2 and 3 to drive expression of the downstream gene construct in the CNS. Western blot analysis showed the MAPT protein to be expressed at levels approximately 5.5 fold higher than the endogenous mouse counterpart.
(J:78400)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:78400 Higuchi M, et al., Transgenic mouse model of tauopathies with glial pathology and nervous system degeneration. Neuron. 2002 Aug 1;35(3):433-46 |
All: |
2 reference(s) |
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