Srf^tm2.2Nor
Targeted Allele Detail

Summary

• Symbol: Srf^tm2.2Nor
• Name: serum response factor; targeted mutation 2.2, Alfred Nordheim
• MGI ID: MGI:2385466
• Synonyms: Srf-flneo
• Gene: Srf Location: Chr17:46859255-46867101 bp, - strand Genetic Position: Chr17, 22.9 cM
• Alliance: Srf^tm2.2Nor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75123
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Disruption caused by insertion of vector
• Mutation details: The floxed region of Srf^tm2Nor containing the entire coding region of exon 1 was excised by the ubiquitous expression of cre recombinase. A floxed neo cassette was left adjoined to a portion of the 5' untranslated region of exon 1. (J:75123)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Srf Mutation: 25 strains or lines available

References

• Original: J:75123 Wiebel FF, et al., Generation of mice carrying conditional knockout alleles for the transcription factor SRF. Genesis. 2002 Feb;32(2):124-6
• All: 1 reference(s)