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Srftm2.2Nor
Targeted Allele Detail
Nomenclature
Symbol: Srftm2.2Nor
Name: serum response factor; targeted mutation 2.2, Alfred Nordheim
MGI ID: MGI:2385466
Synonyms: Srf-flneo
Gene: Srf  Location: Chr17:46546839-46556162 bp, - strand  Genetic Position: Chr17, 22.9 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:75123
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Disruption caused by insertion of vector
 
Mutation detailsThe floxed region of Srftm2Nor containing the entire coding region of exon 1 was excised by the ubiquitous expression of cre recombinase. A floxed neo cassette was left adjoined to a portion of the 5' untranslated region of exon 1. (J:75123)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Srf Mutation:  11 strains or lines available
References
Original:  J:75123 Wiebel FF, et al., Generation of mice carrying conditional knockout alleles for the transcription factor SRF. Genesis. 2002 Feb;32(2):124-6
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory