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Transgene Detail
Symbol: Tg(TLK2mHEL)2Ccg
Name: transgene insertion 2, Christopher C Goodnow
MGI ID: MGI:2385453
Synonyms: thyroHEL, TLK-2
Transgene: Tg(TLK2mHEL)2Ccg  Location: unknown  
Strain of Origin:  C57BL/6JSfd
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Mutation detailsA genomic fragment containing the coding exons of the chicken lysozyme gene (also known as hen egg lysozyme, HEL) was linked to a 3.3kb fragment of the rat thyroglobulin promoter and to the mouse H2-Kb transmembrane sequence (which included the extracellular spacer sequence, transmembrane segment, and cytoplasmic tail). Thyroids from mice carrying the transgene showed expression of chicken lysozyme by Western blot; spleen, islets, and thymus did not. (J:78309)
Inheritance:    Not Specified
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:78309 Akkaraju S, et al., A range of CD4 T cell tolerance: partial inactivation to organ-specific antigen allows nondestructive thyroiditis or insulitis. Immunity. 1997 Aug;7(2):255-71
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
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