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Tg(TLK2mHEL)2Ccg
Transgene Detail
Nomenclature
Symbol: Tg(TLK2mHEL)2Ccg
Name: transgene insertion 2, Christopher C Goodnow
MGI ID: MGI:2385453
Synonyms: thyroHEL, TLK-2
Transgene: Tg(TLK2mHEL)2Ccg  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6JSfd
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsA genomic fragment containing the coding exons of the chicken lysozyme gene (also known as hen egg lysozyme, HEL) was linked to a 3.3kb fragment of the rat thyroglobulin promoter and to the mouse H2-Kb transmembrane sequence (which included the extracellular spacer sequence, transmembrane segment, and cytoplasmic tail). Thyroids from mice carrying the transgene showed expression of chicken lysozyme by Western blot; spleen, islets, and thymus did not. (J:78309)
Inheritance:    Not Specified
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:78309 Akkaraju S, et al., A range of CD4 T cell tolerance: partial inactivation to organ-specific antigen allows nondestructive thyroiditis or insulitis. Immunity. 1997 Aug;7(2):255-71
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory