Tg(TLK2mHEL)2Ccg
Transgene Detail

Summary

• Symbol: Tg(TLK2mHEL)2Ccg
• Name: transgene insertion 2, Christopher C Goodnow
• MGI ID: MGI:2385453
• Synonyms: thyroHEL, TLK-2
• Transgene: Tg(TLK2mHEL)2Ccg Location: unknown
• Alliance: Tg(TLK2mHEL)2Ccg page

Transgene origin

• Strain of Origin: C57BL/6JSfd

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A genomic fragment containing the coding exons of the chicken lysozyme gene (also known as hen egg lysozyme, HEL) was linked to a 3.3kb fragment of the rat thyroglobulin promoter and to the mouse H2-K^b transmembrane sequence (which included the extracellular spacer sequence, transmembrane segment, and cytoplasmic tail). Thyroids from mice carrying the transgene showed expression of chicken lysozyme by Western blot; spleen, islets, and thymus did not. (J:78309)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:78309 Akkaraju S, et al., A range of CD4 T cell tolerance: partial inactivation to organ-specific antigen allows nondestructive thyroiditis or insulitis. Immunity. 1997 Aug;7(2):255-71
• All: 2 reference(s)