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Mdm2tm2.2Glo
Targeted Allele Detail
Nomenclature
Symbol: Mdm2tm2.2Glo
Name: transformed mouse 3T3 cell double minute 2; targeted mutation 2.2, Guillermina Lozano
MGI ID: MGI:2385442
Synonyms: delta exons5/6-neo
Gene: Mdm2  Location: Chr10:117688888-117710758 bp, - strand  Genetic Position: Chr10, 66.32 cM, cytoband C1-C3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:75118
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Disruption caused by insertion of vector
 
Mutation detailsThe expression of Cre recombinase in the germline resulted in the excision of the floxed region containing exons 5 and 6, leaving the floxed neo cassette in intron 6 intact. (J:75118)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mdm2 Mutation:  43 strains or lines available
References
Original:  J:75118 Grier JD, et al., Conditional allele of mdm2 which encodes a p53 inhibitor. Genesis. 2002 Feb;32(2):145-7
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/10/2017
MGI 6.10
The Jackson Laboratory