Tg(Bglap-ESR1-delta3)FVld
Transgene Detail

Summary

• Symbol: Tg(Bglap-ESR1-delta3)FVld
• Name: transgene insertion F, Vicki L Davis
• MGI ID: MGI:2384728
• Synonyms: ERdelta3, TgN(mERdelta3os)06Eme
• Transgene: Tg(Bglap-ESR1-delta3)FVld Location: unknown
• Alliance: Tg(Bglap-ESR1-delta3)FVld page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Dominant negative, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The human ESR1 gene carrying a natural deletion of exon 3 due to alternative splicing was used as the transgene. 200 kb of truncated rat Bglap promoter sequences was used to drive expression of the transgene. The promoter truncation results in loss of tissue-specific expression, therefore expression of the transgene is found in most tissues. The exon 3 deletion results in a dominant negative form of the protein lacking the second zinc finger of the DNA-binding domain, and acts as a repressor of ESR1. (J:77730)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

100% of female transgenic animals spontaneously develop lens opacity at 3 months of age.

References

• Original: J:77730 Davis VL, et al., An estrogen receptor repressor induces cataract formation in transgenic mice. Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9427-32
• All: 2 reference(s)