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Transgene Detail
Symbol: Tg(KLK4mHEL)6Ccg
Name: transgene insertion 6, Christopher C Goodnow
MGI ID: MGI:2384632
Synonyms: KLK3, KLK-4, mHEL, mHEL-KK
Transgene: Tg(KLK4mHEL)6Ccg  Location: unknown  
Strain of Origin:  C57BL/6JSfd
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(KLK4mHEL)6Ccg expresses 2 genes
Mutation detailsA genomic fragment containing the coding exons of the chicken lysozyme gene (also known as hen egg lysozyme, HEL) was linked to the ubiquitously-active mouse H2-Kb promoter and transmembrane sequence (which included the extracellular spacer sequence, transmembrane segment, and cytoplasmic tail). Fluorescence activated cell sorting (FACS) analysis of cells from spleen, lymph node, bone marrow, and thymus from mice carrying the transgene showed membrane expression of chicken lysozyme on these cells. (J:78307)
Inheritance:    Not Specified
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Original:  J:78307 Hartley SB, et al., Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens. Nature. 1991 Oct 24;353(6346):765-9
All:  26 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory