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Slc8a1tm1Yin
Targeted Allele Detail
Nomenclature
Symbol: Slc8a1tm1Yin
Name: solute carrier family 8 (sodium/calcium exchanger), member 1; targeted mutation 1, Yo-ichi Nabeshima
MGI ID: MGI:2384549
Synonyms: Ncx1 -
Gene: Slc8a1  Location: Chr17:81373105-81738377 bp, - strand  Genetic Position: Chr17, 51.29 cM
Slc8a1tm1Yin/Slc8a1tm1Yin embryos lack identifiable vitelline blood vessels

Show the 4 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:65985
Parent Cell Line:  A3-1 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin selection cassette replaced a fragment of the gene containing most of exon 2. Northern blot analysis demonstrated that no detectable transcript was expressed from this allele. (J:65985)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 13 assay results
In Structures Affected by this Mutation: 10 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc8a1 Mutation:  1 strain or line available
References
Original:  J:65985 Wakimoto K, et al., Targeted disruption of Na+/Ca2+ exchanger gene leads to cardiomyocyte apoptosis and defects in heartbeat. J Biol Chem. 2000 Nov 24;275(47):36991-8
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory