Tg(Ins1-BCL2L1)1Ksp
Transgene Detail

Summary

• Symbol: Tg(Ins1-BCL2L1)1Ksp
• Name: transgene insertion 1, Kenneth S Polonsky
• MGI ID: MGI:2384544
• Synonyms: Fd 1 Bcl-xL
• Transgene: Tg(Ins1-BCL2L1)1Ksp Location: unknown
• Alliance: Tg(Ins1-BCL2L1)1Ksp page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Ins1-BCL2L1)1Ksp expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  BCL2L1 (598)

  Bcl2l1

  (MGI:88139)

• Mutation details: 0.82 kb of human BCL2L1 cDNA preceded by 0.5 kb of rat insulin 1 promoter sequences was used for the transgene. Specific expression of the transgene in beta-cells of the pancreas was confirmed by immunohistochemical analysis. Protein staining was detected in beta-cells of transgenic animals, but not in non-beta-cells, liver, exocrine tissue, small intestine, or lymph nodes. Western blot analysis showed expression of the human protein was 2- to 3-fold that of endogenous protein. (J:78000)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:78000 Zhou YP, et al., Overexpression of Bcl-x(L) in beta-cells prevents cell death but impairs mitochondrial signal for insulin secretion. Am J Physiol Endocrinol Metab. 2000 Feb;278(2):E340-51
• All: 2 reference(s)