Slc8a1tm1Sjc
Targeted Allele Detail
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Symbol: |
Slc8a1tm1Sjc |
Name: |
solute carrier family 8 (sodium/calcium exchanger), member 1; targeted mutation 1, Simon J Conway |
MGI ID: |
MGI:2384543 |
Synonyms: |
Ncx1-, Ncx1 -, Ncx1lacZ |
Gene: |
Slc8a1 Location: Chr17:81680534-82045806 bp, - strand Genetic Position: Chr17, 51.29 cM
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Alliance: |
Slc8a1tm1Sjc page
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Germline Transmission: |
Earliest citation of germline transmission:
J:69362
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129X1/SvJ
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Allele Type: |
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Targeted (Null/knockout, Reporter) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A lacZ gene and a neomycin selection cassette replaced the putative translation start site and an additional 1244 bp of coding sequence in exon 2. In situ hybridization experiments confirmed that no detectable mRNA was expressed in E9.0 homozygous embryos.
(J:69362)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Slc8a1 Mutation: |
55 strains or lines available
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Original: |
J:69362 Koushik SV, et al., Targeted inactivation of the sodium-calcium exchanger (Ncx1) results in the lack of a heartbeat and abnormal myofibrillar organization. FASEB J. 2001 May;15(7):1209-11 |
All: |
16 reference(s) |
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