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Slc8a1tm1Sjc
Targeted Allele Detail
Nomenclature
Symbol: Slc8a1tm1Sjc
Name: solute carrier family 8 (sodium/calcium exchanger), member 1; targeted mutation 1, Simon J Conway
MGI ID: MGI:2384543
Synonyms: Ncx1-, Ncx1 -, Ncx1lacZ
Gene: Slc8a1  Location: Chr17:81373105-81738377 bp, - strand  Genetic Position: Chr17, 51.29 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:69362
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA lacZ gene and a neomycin selection cassette replaced the putative translation start site and an additional 1244 bp of coding sequence in exon 2. In situ hybridization experiments confirmed that no detectable mRNA was expressed in E9.0 homozygous embryos. (J:69362)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 50 assay results
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc8a1 Mutation:  1 strain or line available
References
Original:  J:69362 Koushik SV, et al., Targeted inactivation of the sodium-calcium exchanger (Ncx1) results in the lack of a heartbeat and abnormal myofibrillar organization. FASEB J. 2001 May;15(7):1209-11
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory