Rps6ka4^tm1.1Gsc
Targeted Allele Detail

Summary

• Symbol: Rps6ka4^tm1.1Gsc
• Name: ribosomal protein S6 kinase, polypeptide 4; targeted mutation 1.1, Gunther Schutz
• MGI ID: MGI:2384531
• Synonyms: RSK-B/MSK2^flox
• Gene: Rps6ka4 Location: Chr19:6806578-6818004 bp, - strand Genetic Position: Chr19, 5.08 cM
• Alliance: Rps6ka4^tm1.1Gsc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75113
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Two exons encoding the amino terminal ATP-binding domain (residues 44 through 154) were flanked by loxP sites. Prior to blastocyst injection, an FRT flanked neomycin selection cassette was excised by the expression of FLP recombinase within targeted ES cells. (J:75113)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rps6ka4 Mutation: 35 strains or lines available

References

• Original: J:75113 Casanova E, et al., Construction of a conditional allele of RSK-B/MSK2 in the mouse. Genesis. 2002 Feb;32(2):158-60
• All: 1 reference(s)