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Targeted Allele Detail
Symbol: Prss8tm1.1Hum
Name: protease, serine 8 (prostasin); targeted mutation 1.1, Edith Hummler
MGI ID: MGI:2384520
Synonyms: Prss8delta
Gene: Prss8  Location: Chr7:127925716-127930104 bp, - strand  Genetic Position: Chr7, 69.84 cM
Early postnatal lethality and skin abnormalities in Prss8tm1.1Hum/Prss8tm1.2Hum Tg(KRT14-cre)1Ipc/0 mice

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:75109
Parent Cell Line:  GS1 (ES Cell)
Strain of Origin:  129/Sv
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsBreeding of mice carrying Prss8tm1Hum with transgenic mice expressing cre via the EIIa promoter resulted in the excision of the floxed region containing exons 3 through 5. The FRT flanked neo cassette inserted into intron 2 remained intact. (J:75109)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Prss8 Mutation:  17 strains or lines available
Original:  J:75109 Rubera I, et al., A conditional allele at the mouse channel activating protease 1 (Prss8) gene locus. Genesis. 2002 Feb;32(2):173-6
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.03
The Jackson Laboratory