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H2-DMatm1Doi
Targeted Allele Detail
Nomenclature
Symbol: H2-DMatm1Doi
Name: histocompatibility 2, class II, locus DMa; targeted mutation 1, Christophe Benoist and Diane Mathis
MGI ID: MGI:2384509
Synonyms: DM0, H2-DMatm1Dim, H-2Mo, Ma-, Mo
Gene: H2-DMa  Location: Chr17:34135182-34139101 bp, + strand  Genetic Position: Chr17, 17.98 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:31624
Parent Cell Line:  P1 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsSequence encompassing all of exon 1 and a portion of exon 2 was replaced by a neomycin selection cassette. Transcript was undetected in homozygous mutant mice via RT-PCR analysis of total spleen RNA. (J:31624)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any H2-DMa Mutation:  14 strains or lines available
References
Original:  J:31624 Miyazaki T, et al., Mice lacking H2-M complexes, enigmatic elements of the MHC class II peptide-loading pathway. Cell. 1996 Feb 23;84(4):531-41
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory