About   Help   FAQ
H2-DMatm1Doi
Targeted Allele Detail
Nomenclature
Symbol: H2-DMatm1Doi
Name: histocompatibility 2, class II, locus DMa; targeted mutation 1, Christophe Benoist and Diane Mathis
MGI ID: MGI:2384509
Synonyms: DM0, H2-DMatm1Dim, H-2Mo, Ma-, Mo
Gene: H2-DMa  Location: Chr17:34135182-34139101 bp, + strand  Genetic Position: Chr17, 17.98 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:31624
Parent Cell Line:  P1 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsSequence encompassing all of exon 1 and a portion of exon 2 was replaced by a neomycin selection cassette. Transcript was undetected in homozygous mutant mice via RT-PCR analysis of total spleen RNA. (J:31624)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any H2-DMa Mutation:  16 strains or lines available
References
Original:  J:31624 Miyazaki T, et al., Mice lacking H2-M complexes, enigmatic elements of the MHC class II peptide-loading pathway. Cell. 1996 Feb 23;84(4):531-41
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/10/2017
MGI 6.10
The Jackson Laboratory