Stat3^tm1Vpo
Targeted Allele Detail

Summary

• Symbol: Stat3^tm1Vpo
• Name: signal transducer and activator of transcription 3; targeted mutation 1, Valeria Poli
• MGI ID: MGI:2384507
• Synonyms: STAT3^fl
• Gene: Stat3 Location: Chr11:100777632-100830447 bp, - strand Genetic Position: Chr11, 63.82 cM
• Alliance: Stat3^tm1Vpo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67357
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 12 through 14 were left flanked by single intronic loxP sites after a neo transgene was excised from intron 11 via the in vitro expression of cre recombinase. (J:67357)

Disease models

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stat3 Mutation: 70 strains or lines available

References

• Original: J:67357 Alonzi T, et al., Essential role of STAT3 in the control of the acute-phase response as revealed by inducible gene activation in the liver. Mol Cell Biol. 2001 Mar;21(5):1621-32
• All: 58 reference(s)