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Targeted Allele Detail
Symbol: Lta/Tnftm1Jods
Name: tumor necrosis factor; targeted mutation 1, Jonathon D Sedgwick
MGI ID: MGI:2384506
Synonyms: B6.TNF/LTalpha-, TNF-alpha-/LTalpha-, TNF/LTalpha-
Gene: Tnf  Location: Chr17:35199381-35202007 bp, - strand  Genetic Position: Chr17, 18.59 cM
Germline Transmission:  Earliest citation of germline transmission: J:43602
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  C57BL/6
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intergenic deletion
Mutation detailsThe insertion of a neomycin selection cassette replaced approximately 4.0 kb of sequence, containing the entire coding region of Lta and exons 1 through 3 of Tnf. RT-PCR analysis indicated that transcript was not produced from the targeted loci. (J:43602)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tnf Mutation:  35 strains or lines available
ES cell lines = BL/6-III or Bruce 4
Original:  J:43602 Korner H, et al., Distinct roles for lymphotoxin-alpha and tumor necrosis factor in organogenesis and spatial organization of lymphoid tissue. Eur J Immunol. 1997 Oct;27(10):2600-9
All:  24 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
The Jackson Laboratory