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Etv1tm1Tmj
Targeted Allele Detail
Nomenclature
Symbol: Etv1tm1Tmj
Name: ets variant 1; targeted mutation 1, Thomas M Jessell
MGI ID: MGI:2384493
Synonyms: Er81ETS
Gene: Etv1  Location: Chr12:38780082-38870483 bp, + strand  Genetic Position: Chr12, 17.99 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:78232
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA construct containing an IRES-tau-lacZ cassette inserted in place of exon 11 was incorporated into the endogenous locus via homologous recombination. The insertion disrupted sequence encoding part the ETS domain and inserted stop codons into all three reading frames. Normal protein was undetected in homozygous mutant mice. No beta-galactosidase activity is detected. (J:78232)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Etv1 Mutation:  30 strains or lines available
References
Original:  J:78232 Arber S, et al., ETS gene Er81 controls the formation of functional connections between group Ia sensory afferents and motor neurons. Cell. 2000 May 26;101(5):485-98
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory