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Ccl11tm1Brv
Targeted Allele Detail
Nomenclature
Symbol: Ccl11tm1Brv
Name: chemokine (C-C motif) ligand 11; targeted mutation 1, Rodrigo Bravo
MGI ID: MGI:2384431
Synonyms: eotaxin-
Gene: Ccl11  Location: Chr11:82057832-82062955 bp, + strand  Genetic Position: Chr11, 49.84 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:78283
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAn in frame insertion of lacZ after sequence encoding the first four amino acids replaced the remainder of exon 1 and all of exon 2. No endogenous transcript was detected in homozygous mutant mice via Northern blot analysis of lymph node RNA. Expression realized by Xgal staining only partially coincided with RT-PCR analysis and previous results. (J:78283)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ccl11 Mutation:  10 strains or lines available
References
Original:  J:78283 Yang Y, et al., Antigen-induced eosinophilic lung inflammation develops in mice deficient in chemokine eotaxin. Blood. 1998 Nov 15;92(10):3912-23
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory