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Targeted Allele Detail
Symbol: Hnf1atm1.1Ylee
Name: HNF1 homeobox A; targeted mutation 1.1, Ying-Hue Lee
MGI ID: MGI:2384429
Synonyms: hnf1alpha-, Hnf-1alpha-
Gene: Hnf1a  Location: Chr5:114948980-114971094 bp, - strand  Genetic Position: Chr5, 55.99 cM, cytoband F
Germline Transmission:  Earliest citation of germline transmission: J:47008
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsThis allele was generated by breeding mice carrying Tcf1tm1Ylee with transgenic mice expressing cre via the EIIa promoter. Cre mediated excision of the floxed fragment, containing the coding region of exon 1 and the neo transgene inserted into intron 1, resulted in the loss of sequence encoding 108 amino acids as well as a portion of intron 1. Transcript was undetected in homozygous mutant mice via RT-PCR analysis. (J:47008)
View phenotypes for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 30 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hnf1a Mutation:  7 strains or lines available
Original:  J:47008 Lee YH, et al., Laron dwarfism and non-insulin-dependent diabetes mellitus in the Hnf-1alpha knockout mouse. Mol Cell Biol. 1998 May;18(5):3059-68
All:  21 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.0
The Jackson Laboratory