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Slc8a1tm1Hssh
Targeted Allele Detail
Nomenclature
Symbol: Slc8a1tm1Hssh
Name: solute carrier family 8 (sodium/calcium exchanger), member 1; targeted mutation 1, Hee-Sup Shin
MGI ID: MGI:2384413
Synonyms: NCX1-
Gene: Slc8a1  Location: Chr17:81373105-81738377 bp, - strand  Genetic Position: Chr17, 51.29 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:74096
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA PGK-neo-poly(A) cassette was inserted at the NcoI site located in the first coding exon. This insertion disrupted the coding sequence after amino acid 247, predicting to result in premature termination of the encoded protein. RT-PCR analysis on RNA derived from E9.5 homozygous embryos demonstrated that no detectable transcript was expressed from this allele. (J:74096)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 assay results
In Structures Affected by this Mutation: 10 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc8a1 Mutation:  1 strain or line available
References
Original:  J:74096 Cho CH, et al., The Na+ -Ca2+ exchanger is essential for embryonic heart development in mice. Mol Cells. 2000 Dec 31;10(6):712-22
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory