Foxa1^tm1Stf
Targeted Allele Detail

Summary

• Symbol: Foxa1^tm1Stf
• Name: forkhead box A1; targeted mutation 1, Markus Stoffel
• MGI ID: MGI:2384404
• Synonyms: HNF-3alpha^-
• Gene: Foxa1 Location: Chr12:57587414-57593702 bp, - strand Genetic Position: Chr12, 24.7 cM
• Alliance: Foxa1^tm1Stf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:57493
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The in frame insertion of a cassette containing lacZ and neo genes replaced the majority of exon 2. The deleted region encoded the DNA-binding domain. Transcript was undetected by RT-PCR analysis of homozygous mutant mice. (J:57493)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxa1 Mutation: 20 strains or lines available

References

• Original: J:57493 Shih DQ, et al., Impaired glucose homeostasis and neonatal mortality in hepatocyte nuclear factor 3alpha-deficient mice. Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10152-7
• All: 4 reference(s)