Irak1^tm1Jth
Targeted Allele Detail

Summary

• Symbol: Irak1^tm1Jth
• Name: interleukin-1 receptor-associated kinase 1; targeted mutation 1, James A Thomas
• MGI ID: MGI:2384212
• Synonyms: IRAK-1^-
• Gene: Irak1 Location: ChrX:73057520-73067524 bp, - strand Genetic Position: ChrX, 37.61 cM
• Alliance: Irak1^tm1Jth page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:56156
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 7.0 kb of sequence was replaced by the insertion of neomycin selection cassette. The deleted region included 3.5 kb of the upstream regulatory region, all of exons 1 through 8, and a portion of exon 9. Western blot analysis of mouse embryonic fibroblasts showed an absence of encoded protein in homozygous mutant mice. (J:56156)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Irak1 Mutation: 16 strains or lines available

Notes

ES cell line = E1.1C.

References

• Original: J:56156 Thomas JA, et al., Impaired cytokine signaling in mice lacking the IL-1 receptor-associated kinase. J Immunol. 1999 Jul 15;163(2):978-84
• All: 27 reference(s)