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Targeted Allele Detail
Symbol: Irak1tm1Jth
Name: interleukin-1 receptor-associated kinase 1; targeted mutation 1, James A Thomas
MGI ID: MGI:2384212
Synonyms: IRAK-1-
Gene: Irak1  Location: ChrX:73057520-73067524 bp, - strand  Genetic Position: ChrX, 37.61 cM
Germline Transmission:  Earliest citation of germline transmission: J:56156
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation details7.0 kb of sequence was replaced by the insertion of neomycin selection cassette. The deleted region included 3.5 kb of the upstream regulatory region, all of exons 1 through 8, and a portion of exon 9. Western blot analysis of mouse embryonic fibroblasts showed an absence of encoded protein in homozygous mutant mice. (J:56156)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Irak1 Mutation:  8 strains or lines available
ES cell line = E1.1C.
Original:  J:56156 Thomas JA, et al., Impaired cytokine signaling in mice lacking the IL-1 receptor-associated kinase. J Immunol. 1999 Jul 15;163(2):978-84
All:  27 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory