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Shc1tm1Ravi
Targeted Allele Detail
Nomenclature
Symbol: Shc1tm1Ravi
Name: src homology 2 domain-containing transforming protein C1; targeted mutation 1, Kodi S Ravichandran
MGI ID: MGI:2384183
Synonyms: Shcfl
Gene: Shc1  Location: Chr3:89418443-89430027 bp, + strand  Genetic Position: Chr3, 39.11 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:78180
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsExons 1 and 2, encoding the transcriptional start site and the amino terminals of the three known isoforms, were flanked by a single upstream loxP site and a floxed neo cassette inserted into intron 2. Transient transfection of ES cells resulted in the excision of the floxed neo cassette, leaving the first two exons surrounded by single loxP sites. (J:78180)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Shc1 Mutation:  59 strains or lines available
References
Original:  J:78180 Zhang L, et al., A nonredundant role for the adapter protein Shc in thymic T cell development. Nat Immunol. 2002 Aug;3(8):749-55
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory