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Cfhtm1Mbo
Targeted Allele Detail
Nomenclature
Symbol: Cfhtm1Mbo
Name: complement component factor h; targeted mutation 1, Marina Botto
MGI ID: MGI:2384179
Synonyms: Cfh-, fH-
Gene: Cfh  Location: Chr1:140085855-140183411 bp, - strand  Genetic Position: Chr1, 61.62 cM, cytoband F
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:78193
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 3 was replaced with a neomycin selection cassette. The absence of encoded protein in homozygous mutant mice was confirmed by Western blot analysis. (J:78193)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 12 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cfh Mutation:  57 strains or lines available
References
Original:  J:78193 Pickering MC, et al., Uncontrolled C3 activation causes membranoproliferative glomerulonephritis in mice deficient in complement factor H. Nat Genet. 2002 Aug;31(4):424-8
All:  47 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/23/2021
MGI 6.16
The Jackson Laboratory