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Targeted Allele Detail
Symbol: Cdkn2atm2Brn
Name: cyclin dependent kinase inhibitor 2A; targeted mutation 2, Anton Berns
MGI ID: MGI:2384163
Synonyms: ArfF, Ink4a/ArfF, Ink4aflox, p16INK4a-ARFfl
Gene: Cdkn2a  Location: Chr4:89274473-89294619 bp, - strand  Genetic Position: Chr4, 42.15 cM, cytoband C3-C6
Germline Transmission:  Earliest citation of germline transmission: J:71393
Parent Cell Line:  IB10/E14IB10 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsLoxP sites were inserted 1.0 kb upstream of exon 2 and 1.5 kb downstream of exon 3. Mice carrying this allele were bred with transgenic mice expressing cre recombinase to generate Cdkn2atm2.1Brn. (J:71393)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Cdkn2a Mutation:  50 strains or lines available
Original:  J:71393 Krimpenfort P, et al., Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice. Nature. 2001 Sep 6;413(6851):83-6
All:  22 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory