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Tg(IghelMD4)4Ccg
Transgene Detail
Nomenclature
Symbol: Tg(IghelMD4)4Ccg
Name: transgene insertion 4, Christopher C Goodnow
MGI ID: MGI:2384162
Synonyms: Hel-Ig, HELmuMT, IgHEL, IgTg, Ig-transgenic, MD-3, MD4, MD4 HEL Ig, MD4 Ig, MD4 Ig BCR Tg, MD4-RAG, SWHEL
Transgene: Tg(IghelMD4)4Ccg  Location: unknown  Genetic Position: Chr17, Syntenic
Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(IghelMD4)4Ccg expresses 1 gene
 
Mutation detailsThe hybridoma HyHEL10 produces an antibody with high affinity for hen egg lysozyme. Genomic clones encoding HyHEL10 immunoglobulin heavy and light chains were used for this construct. The gamma1-constant region of the heavy chain was replaced by a segment containing the mu and delta constant region genes derived from BALB/c mice. The light and heavy chains were co-injected into C57BL/6 eggs. Five lines, MD3-MD7, that carried multiple copies of the transgene construct were created. The MD4 line had the highest expression of the transgene and was propogated for further studies. Mice carrying this transgene had high serum titers of anti-lysozyme antibodies. (J:78308)
Inheritance:    Not Specified
Phenotypes
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Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 7 strains available      Cell Lines: 0 lines available
References
Original:  J:78308 Goodnow CC, et al., Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice. Nature. 1988 Aug 25;334(6184):676-82
All:  156 reference(s)

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last database update
04/07/2015
MGI 5.21
The Jackson Laboratory