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Transgene Detail
Symbol: Tg(IghelMD4)4Ccg
Name: transgene insertion 4, Christopher C Goodnow
MGI ID: MGI:2384162
Synonyms: Hel-Ig, HELmuMT, IgHEL, IgHEL, IgTg, Ig-transgenic, MD-3, MD4, MD4 HEL Ig, MD4 Ig, MD4 Ig BCR Tg, MD4-RAG, SWHEL
Transgene: Tg(IghelMD4)4Ccg  Location: unknown  Genetic Position: Chr17, Syntenic
Strain of Origin:  C57BL/6
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(IghelMD4)4Ccg expresses 1 gene
Mutation detailsThe hybridoma HyHEL10 produces an antibody with high affinity for hen egg lysozyme. Genomic clones encoding HyHEL10 immunoglobulin heavy and light chains were used for this construct. The gamma1-constant region of the heavy chain was replaced by a segment containing the mu and delta constant region genes derived from BALB/c mice. The light and heavy chains were co-injected into C57BL/6 eggs. Five lines, MD3-MD7, that carried multiple copies of the transgene construct were created. The MD4 line had the highest expression of the transgene and was propogated for further studies. Mice carrying this transgene had high serum titers of anti-lysozyme antibodies. (J:78308)
Inheritance:    Not Specified
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Original:  J:78308 Goodnow CC, et al., Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice. Nature. 1988 Aug 25;334(6184):676-82
All:  222 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.15
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