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Transgene Detail
Symbol: Tg(ML5sHEL)5Ccg
Name: transgene insertion 5, Christopher C Goodnow
MGI ID: MGI:2384160
Synonyms: MD5, ML5, ML-5, sHEL, solHEL, SWHEL
Transgene: Tg(ML5sHEL)5Ccg  Location: unknown  
Alliance: Tg(ML5sHEL)5Ccg page
Strain of Origin:  C57BL/6JSfd
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(ML5sHEL)5Ccg expresses 2 genes
Mutation detailsA genomic fragment containing the coding exons of the chicken lysozyme gene (also known as hen egg lysozyme, HEL) was linked to a mouse metallothionein I promoter. The mouse metallothionein I promoter is active during embryonic, fetal, and adult life, and can be induced to higher levels of transcription by heavy metals. Mice carrying the transgene had measurable, soluble chicken lysozyme in their serum. The line chosen for study (ML-5) had the highest serum lysozyme concentrations. (J:78308)
Inheritance:    Not Specified
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Original:  J:78308 Goodnow CC, et al., Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice. Nature. 1988 Aug 25;334(6184):676-82
All:  87 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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MGI 6.22
The Jackson Laboratory