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Targeted Allele Detail
Symbol: Ucntm1Klee
Name: urocortin; targeted mutation 1, Kuo-Fen Lee
MGI ID: MGI:2384136
Synonyms: Ucn-
Gene: Ucn  Location: Chr5:31138063-31138829 bp, - strand  Genetic Position: Chr5, 17.11 cM
Germline Transmission:  Earliest citation of germline transmission: J:78199
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe region encoding the mature peptide was deleted by the insertion of a neomycin selection cassette. The absence of transcript in homozygous mutant mice was demonstrated by RNAse protection and in situ hybridization. Western blot analysis of brain tissue confirmed the lack of protein. (J:78199)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ucn Mutation:  1 strain or line available
Original:  J:78199 Vetter DE, et al., Urocortin-deficient mice show hearing impairment and increased anxiety-like behavior. Nat Genet. 2002 Aug;31(4):363-9
All:  5 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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