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Targeted Allele Detail
Symbol: Mpztm1Msch
Name: myelin protein zero; targeted mutation 1, Melitta Schachner
MGI ID: MGI:2384133
Synonyms: P0-
Gene: Mpz  Location: Chr1:171150711-171161130 bp, + strand  Genetic Position: Chr1, 79.05 cM
Germline Transmission:  Earliest citation of germline transmission: J:3234
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 1 encoding the signal peptide was replaced with a neomycin resistance gene via homologous recombination. Southern blot analysis revealed several copies of the targeting vector had integrated as a concatemer in a head-to-tail manner. Western blot analysis of peripheral nerve proteins from homozygous mutant animals confirmed the absence of gene expression. The null allele was further verified by immunohistochemical analysis of femoral nerve sections from homozygous mutant animals using a polyclonal antibody to the protein. No immunoreactive staining was observed. (J:3234)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mpz Mutation:  19 strains or lines available
Original:  J:3234 Giese KP, et al., Mouse P0 gene disruption leads to hypomyelination, abnormal expression of recognition molecules, and degeneration of myelin and axons. Cell. 1992 Nov 13;71(4):565-76
All:  44 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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