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Targeted Allele Detail
Symbol: Cd3etm1.1Lov
Name: CD3 antigen, epsilon polypeptide; targeted mutation 1.1, Paul E Love
MGI ID: MGI:2384123
Synonyms: Cd3e-, Cd3edelta, Cd3epsilon-
Gene: Cd3e  Location: Chr9:44998740-45009627 bp, - strand  Genetic Position: Chr9, 24.84 cM
Germline Transmission:  Earliest citation of germline transmission: J:72144
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsThis allele was generated by breeding mice homozygous for Cd3etm1Lov with transgenic mice expressing cre recombinase via the EIIa promoter, resulting in the excision of the floxed neo. Northern blot analysis of homozygous mutant mice showed normal levels of Cd3d and Cd3g transcript as well as the presence of a truncated Cd3e transcript. Sequencing of Cd3e cDNA derived from RT-PCR analysis showed the splicing of exons 4 to 7 (lacking the extracellular and transmembrane domains). Western blot analysis showed the absence of truncated protein product. (J:72144)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cd3e Mutation:  12 strains or lines available
Original:  J:72144 DeJarnette JB, et al., Specific requirement for CD3epsilon in T cell development. Proc Natl Acad Sci U S A. 1998 Dec 8;95(25):14909-14
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory