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Fshrtm1Saco
Targeted Allele Detail
Nomenclature
Symbol: Fshrtm1Saco
Name: follicle stimulating hormone receptor; targeted mutation 1, Paolo Sassone-Corsi
MGI ID: MGI:2384087
Synonyms: FORKO, Fshr-, FSH-R-
Gene: Fshr  Location: Chr17:88985170-89200612 bp, - strand  Genetic Position: Chr17, 58.76 cM, cytoband E5
Abnormal sperm morphology in Fshrtm1Saco/Fshrtm1Saco mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:50933
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe insertion of a neomycin selection cassette deleted exon 1. Northern blot analysis of testicular and ovarian RNA showed that the deletion was sufficient for abbrogating the expression of all known isoforms. The absence of functional protein in homozygous mutant mice was confirmed by lableled ligand binding assays of testis. (J:50933)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fshr Mutation:  16 strains or lines available
References
Original:  J:50933 Dierich A, et al., Impairing follicle-stimulating hormone (FSH) signaling in vivo: targeted disruption of the FSH receptor leads to aberrant gametogenesis and hormonal imbalance. Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13612-7
All:  33 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory