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Cntn1tm1Brns
Targeted Allele Detail
Nomenclature
Symbol: Cntn1tm1Brns
Name: contactin 1; targeted mutation 1, Barbara Ranscht
MGI ID: MGI:2384082
Synonyms: CNTN-
Gene: Cntn1  Location: Chr15:92051165-92341953 bp, + strand  Genetic Position: Chr15, 46.39 cM, cytoband F
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:58556
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe gene was disrupted by insertion of a PGK-neo cassette into exon 3 via homologous recombination. Absence of protein product in homozygous mutant animals was verified by Western blot analysis of brain homogenates and immunohistochemical analysis of cerebellum sections. Additionally, cerebellar granule cells cultured from homozygous mutants did not immunoprecipitate or stain for protein product. (J:58556)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cntn1 Mutation:  19 strains or lines available
References
Original:  J:58556 Berglund EO, et al., Ataxia and abnormal cerebellar microorganization in mice with ablated contactin gene expression. Neuron. 1999 Nov;24(3):739-50
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory