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Targeted Allele Detail
Symbol: Ccr10/Cntnap1tm1Bhat
Name: contactin associated protein-like 1; targeted mutation 1, Manzoor A Bhat
MGI ID: MGI:2384080
Synonyms: Caspr-, Cntnap1tm1Bhat
Gene: Cntnap1  Location: Chr11:101170523-101190724 bp, + strand  Genetic Position: Chr11, 64.33 cM, cytoband D
Germline Transmission:  Earliest citation of germline transmission: J:69621
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intergenic deletion
Mutation detailsA targeting vector disrupted two genes via homologous recombination. Regulatory sequences and the first 7 exons of the Cntnap1 gene were replaced with a neomycin resistance cassette, as were the first two coding exons of the Ccr10 gene. Loss of Cntnap1 gene expression in homozygous mutants was demonstrated by Western blot analysis of whole brain and sciatic nerve homogenates and by immunohistochemistry of sciatic nerves and CNS. Effects on Ccr10 gene expression were not examined though it was predicted to be a null allele due to the removal of the transcription start site for the gene. (J:69621)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cntnap1 Mutation:  33 strains or lines available
Original:  J:69621 Bhat MA, et al., Axon-glia interactions and the domain organization of myelinated axons requires neurexin iv/caspr/paranodin. Neuron. 2001 May;30(2):369-83
All:  6 reference(s)

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MGI 6.11
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