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Targeted Allele Detail
Symbol: Cptm1Samd
Name: ceruloplasmin; targeted mutation 1, Samuel David
MGI ID: MGI:2384067
Synonyms: Cp-
Gene: Cp  Location: Chr3:19957054-20009145 bp, + strand  Genetic Position: Chr3, 6.1 cM, cytoband D
Germline Transmission:  Earliest citation of germline transmission: J:78092
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 3 kb region of the gene including exon 1 and the translation initiation site was replaced with a neomycin resistance cassette via homologous recombination. Southern blot analysis confirmed correct targeting of the allele and Western blot of plasma confirmed the absence of gene expression in homozygous mutant animals. (J:78092)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cp Mutation:  33 strains or lines available
Original:  J:78092 Patel BN, et al., Ceruloplasmin regulates iron levels in the CNS and prevents free radical injury. J Neurosci. 2002 Aug 1;22(15):6578-86
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.06
The Jackson Laboratory