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Targeted Allele Detail
Symbol: Pafah1b1tm2Awb
Name: platelet-activating factor acetylhydrolase, isoform 1b, subunit 1; targeted mutation 2, Anthony Wynshaw-Boris
MGI ID: MGI:2384060
Synonyms: Lis1-loxP, Pafah1b1-loxP, Pafah1b1loxPex3-6
Gene: Pafah1b1  Location: Chr11:74673949-74724670 bp, - strand  Genetic Position: Chr11, 45.76 cM, cytoband B3
Germline Transmission:  Earliest citation of germline transmission: J:49531
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Conditional ready, Hypomorph)
Mutation:    Insertion
Mutation detailsA floxed PGK-neo cassette was inserted into intron 2 and a third loxP site was introduced into intron 6 via homologous recombination. This allele is hypomorphic, because of disruption of transcription or splicing by the insertion of a phosphoglycerate kinase neomycin cassette from the targeting vector into the second intron (J:82268). (J:49531)
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pafah1b1 Mutation:  151 strains or lines available
Original:  J:49531 Hirotsune S, et al., Graded reduction of Pafah1b1 (Lis1) activity results in neuronal migration defects and early embryonic lethality [see comments]. Nat Genet. 1998 Aug;19(4):333-9
All:  11 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.07
The Jackson Laboratory