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Targeted Allele Detail
Symbol: Hcktm1Hev
Name: hemopoietic cell kinase; targeted mutation 1, Harold E Varmus
MGI ID: MGI:2384049
Synonyms: hck-
Gene: Hck  Location: Chr2:153108468-153151441 bp, + strand  Genetic Position: Chr2, 75.41 cM
Germline Transmission:  Earliest citation of germline transmission: J:16994
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsThis dicistronic locus was disrupted by the insertion of a neomycin selection cassette downstream of both start codons. Elongated transcript, containing the neo transgene, and a shortened transcript, resulting from the splicing of exons 1 and 3, were detected in homozygous mutant mice by Northern blot and RT-PCR analyses. Normal protein was undetected by Western blot analysis of bone marrow, and though the absence of truncated carboxy terminal peptide was not directly confirmed, assays of immunoprecipitates verified a lack of protein kinase activity. (J:16994)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hck Mutation:  5 strains or lines available
Original:  J:16994 Lowell CA, et al., Functional overlap in the src gene family: inactivation of hck and fgr impairs natural immunity. Genes Dev. 1994 Feb 15;8(4):387-98
All:  57 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.15
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