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Targeted Allele Detail
Symbol: Fgrtm1Hev
Name: FGR proto-oncogene, Src family tyrosine kinase; targeted mutation 1, Harold E Varmus
MGI ID: MGI:2384040
Synonyms: fgr-, fgr-deltaE2
Gene: Fgr  Location: Chr4:132974095-133001910 bp, + strand  Genetic Position: Chr4, 66.11 cM
Germline Transmission:  Earliest citation of germline transmission: J:16994
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsExon 2 was disrupted by the insertion of a neomycin selection cassette. While Northern blot analysis of LPS activated macrophages showed the absence of normal and truncated transcripts, elongated transcript containing the neo transgene was detected in homozygous mutant mice. Normal protein was undetected by Western blot analysis, and though the absence of truncated carboxy terminal peptide was not directly confirmed, assays of bone marrow derived macrophages verified a lack of protein kinase activity. (J:16994, J:102347)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fgr Mutation:  120 strains or lines available
Original:  J:16994 Lowell CA, et al., Functional overlap in the src gene family: inactivation of hck and fgr impairs natural immunity. Genes Dev. 1994 Feb 15;8(4):387-98
All:  47 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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