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Targeted Allele Detail
Symbol: Fgf1tm1Bas
Name: fibroblast growth factor 1; targeted mutation 1, Claudio Basilico
MGI ID: MGI:2383991
Synonyms: FGF1-
Gene: Fgf1  Location: Chr18:38838673-38929404 bp, - strand  Genetic Position: Chr18, 20.74 cM
Germline Transmission:  Earliest citation of germline transmission: J:60597
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 1 and surrounding genomic sequence were replaced with a PGK-neo casstte. The absence of encoded protein in homozygous mutant mice was determined via Western blot analysis of extracts from various tissues. (J:60597)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fgf1 Mutation:  35 strains or lines available
Original:  J:60597 Miller DL, et al., Compensation by fibroblast growth factor 1 (FGF1) does not account for the mild phenotypic defects observed in FGF2 null mice [published erratum appears in Mol Cell Biol 2000 May;20(10):3752]. Mol Cell Biol. 2000 Mar;20(6):2260-8
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory