Fdft1^tm1Yma
Targeted Allele Detail

Summary

• Symbol: Fdft1^tm1Yma
• Name: farnesyl diphosphate farnesyl transferase 1; targeted mutation 1, Nobuhiro Yamada
• MGI ID: MGI:2383989
• Synonyms: SS-
• Gene: Fdft1 Location: Chr14:63382599-63417027 bp, - strand Genetic Position: Chr14, 33.24 cM
• Alliance: Fdft1^tm1Yma page

Growth retardation and defective neural tube closure in Fdft1^tm1Yma/Fdft1^tm1Yma embryos

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:58231
• Parent Cell Line: JH1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 4 and 5 were replaced with a neomycin selection cassette. Northern blot analysis of total hepatic RNA from heterozygous mice showed transcript levels to be reduced to 40% of normal. Squalene synthase activity was determined to be reduced by 50% in heterozygous mice via an assay of liver and testis homogenates. (J:58231)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fdft1 Mutation: 47 strains or lines available

References

• Original: J:58231 Tozawa R, et al., Embryonic lethality and defective neural tube closure in mice lacking squalene synthase. J Biol Chem. 1999 Oct 22;274(43):30843-8
• All: 1 reference(s)