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Targeted Allele Detail
Symbol: Ercc2tm1Jhjh
Name: excision repair cross-complementing rodent repair deficiency, complementation group 2; targeted mutation 1, Jan H J Hoeijmakers
MGI ID: MGI:2183947
Synonyms: TTD-, XPD0
Gene: Ercc2  Location: Chr7:19382010-19395694 bp, + strand  Genetic Position: Chr7, 9.62 cM
Germline Transmission:  Earliest citation of germline transmission: J:45017
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprtb-m3
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsAll of exons 17 through 21 and a portion of exon 22 were replaced by a cassette containing neo and hprt transgenes. The insertion is upstream of sequence encoding the DNA helicase domains 4 through 6 and the putative DNA-binding domain. The potential excision of the cassette generates a frameshift mutation via the splicing of exons 16 and 23. The targeting vector was designed such that it would not interfere with the Klc3 locus on the antisense strand. (J:45017)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ercc2 Mutation:  14 strains or lines available
Original:  J:45017 de Boer J, et al., Disruption of the mouse xeroderma pigmentosum group D DNA repair/basal transcription gene results in preimplantation lethality. Cancer Res. 1998 Jan 1;58(1):89-94
All:  5 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory