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Targeted Allele Detail
Symbol: Klf4tm1Efu
Name: Kruppel-like factor 4 (gut); targeted mutation 1, Elaine Fuchs
MGI ID: MGI:2183936
Synonyms: Klf4-
Gene: Klf4  Location: Chr4:55527143-55532466 bp, - strand  Genetic Position: Chr4, 29.76 cM
Germline Transmission:  Earliest citation of germline transmission: J:56495
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 2.8 kb region of the gene encompassing part of exon 1, exon 2, and exon 3 was replaced with a PGK-neo cassette via homologous recombination. The targeted region encodes the translation initiation codon and the first of 3 zinc finger domains. Northern blot analysis and immunohistochemistry of skin sections from homozygous mutant animals verified the absence of gene expression. (J:56495)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 51 assay results
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Klf4 Mutation:  18 strains or lines available
Original:  J:56495 Segre JA, et al., Klf4 is a transcription factor required for establishing the barrier function of the skin. Nat Genet. 1999 Aug;22(4):356-60
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
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