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Targeted Allele Detail
Symbol: Xpatm1Tnka
Name: xeroderma pigmentosum, complementation group A; targeted mutation 1, Kiyoji Tanaka
MGI ID: MGI:2183931
Synonyms: XPA-
Gene: Xpa  Location: Chr4:46155347-46196311 bp, - strand  Genetic Position: Chr4, 24.49 cM, cytoband C2
Germline Transmission:  Earliest citation of germline transmission: J:28709
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  (C57BL/6 x CBA)F1
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsExon 4 was disrupted by the insertion of a neomycin selection cassette. Encoded protein was undetected in homozygous mutant mice by Western blot analysis of splenocyte extracts. (J:28709)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Xpa Mutation:  13 strains or lines available
ES cell line = F1/1 ES (established from the F1 hybrid of male CBA and female C57BL/6).
Phenotypic Similarity to Human Syndrome: Cutaneous Malignant Melanoma in mice homozygous for this allele and hemizygous for Tg(KRT14-Kitl)1Takk
Original:  J:28709 Nakane H, et al., High incidence of ultraviolet-B-or chemical-carcinogen-induced skin tumours in mice lacking the xeroderma pigmentosum group A gene. Nature. 1995 Sep 14;377(6545):165-8
All:  31 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.09
The Jackson Laboratory